Polymyxin B-direct hemoperfusion therapy contributes to oxygen delivery in septic patients
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چکیده
منابع مشابه
Polymyxin B-immobilized fiber column hemoperfusion therapy for septic shock.
Endotoxin, an outer membrane component of gram-negative bacteria, plays an important role in the pathogenesis of septic shock. Endotoxin adsorption therapy by polymyxin B-immobilized fiber column hemoperfusion (PMX) has been used for the treatment of septic shock patients in Japan since 1994. The covalent binding of polymyxin B onto the surface of the polystyrene-based carrier fiber in PMX inac...
متن کاملTime to initiation of treatment with polymyxin B cartridge hemoperfusion in septic shock patients.
BACKGROUND We investigated whether early initiation of hemoperfusion with a polymyxin B cartridge (PMX) after the diagnosis of septic shock could improve the clinical outcome. METHODS A prospective, open-labeled, multicenter cohort study was performed at intensive care units in Japan. 41 patients received PMX within 6 h after the diagnosis of septic shock (early group) and 51 patients were tr...
متن کاملDirect hemoperfusion using polymyxin-B immobilized fiber for septic shock after cardiac surgery.
BACKGROUND The factors contributing to the efficacy and outcome of direct hemoperfusion using polymyxin-B immobilized fiber (PMX-DHP) after cardiac surgery were investigated. METHODS AND RESULTS In 23 patients who received PMX-DHP for shock related to infection after cardiac surgery, there were no differences in the pre- and intraoperative clinical data of survivors (n=14) and non-survivors (...
متن کاملPolymyxin B Hemoperfusion for Septic Shock -- Ready for Primetime? Early Use of Polymyxin B Hemoperfusion in Abdominal Septic Shock: The EUPHAS Randomized Controlled Trial
Background: Treatments for severe sepsis are limited, and its morbidity and mortality, especially from Gramnegative organisms, continues to be significant. Gram-negative organisms release endotoxin, which initiates inflammatory and coagulation cascades, resulting in end-organ dysfunction in patients. Polymyxin B hemoperfusion filters bind endotoxin. Objective: To assess the efficacy of polymyxi...
متن کاملAngiopoietin Balance in Septic Shock Patients With Acute Kidney Injury: Effects of Direct Hemoperfusion With Polymyxin B-Immobilized Fiber.
Acute kidney injury (AKI) occurs in approximately 50% of patients in septic shock, and mortality from septic AKI is extremely high. Angiopoietin levels may play a role in the pathogenesis of vascular permeability. It was reported that direct hemoperfusion with a polymyxin B-immobilized fiber column (DHP-PMX) therapy ameliorates the angiopoietin balance in patients with sepsis. Although dysregul...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2012
ISSN: 1364-8535
DOI: 10.1186/cc11744